pulmonary chloroma radiology

Granulocytic sarcoma (chloroma) is an unusual extramedullary manifestation of acute myelogenous leukemia, chronic myelogenous leukemia, and the myeloproliferative syndrome. Marcos D. Guimarães, Edson Marchiori, Edith M. Marom, Mark J. Routbort, Myrna C. B. Godoy, Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia, Annals of Hematology, 10.1007/s00277-013-1768-3, 93, 2, (327-328), (2013). A Bronchial Chloroma Saadia A. Faiz1, Nelson G. Ordonez2, Rodolfo C. Morice1, Lara Bashoura1, and Carlos A. Jimenez1 1Department of Pulmonary Medicine, and 2Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas Figure 1. MRI with sacral mass. 330 Accesses. Radiology images. Takasugi JE, Godwin JD, Marglin SI, Petersdorf SH. (A) Radiographic imaging at time of presentation. Myeloid sarcoma, previously called granulocytic sarcoma or chloroma, is an extramedullary manifestation of leukemia, most often seen in the monocytic form of acute myeloid leukemia (AML). On magnetic resonance imaging (MRI) scans, chordomas show a signal heterogeneity, possibly due to a variety of components, including fluid and gelatinous mucoid substance (associated with recent and old hemorrhage) and necrotic areas within the tumor (see the following images). 1994;190:698–702. The imaging appearance of mediastinal granulocytic sarcomas is not specific with a wide differential diagnosis including lymphoma, thymoma, teratoma, infection/mediastinitis/abscess and haematoma. An unusual case of pulmonary granulocytic sarcoma treated with combined chemotherapy and radiation. Myeloid sarcoma may arise before, concurrent with, or after the diagnosis of AML, chronic myelogenous leukemia (CML), or myelodysplastic syndrome (MDS) is made. Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia. Rare; case reports of ages 24 - 68 years Pathophysiology. The term chloroma is derived from the characteristic green color resulting from the high levels of the intracellular porphyrin-bearing enzyme myeloperoxidase. Myeloid sarcoma (MS), or granulocytic sarcoma, is a tumoral lesion consisting of immature myeloid cells, mainly myeloblasts of granulocytic series - representing a focal accumulation of leukemic cells. Acute Myelogenous Leukemia; Chloroma; Granulocytic Sarcoma; Heart . The authors declare no conflict of interest. Contributed by Jesse Hart, D.O. Granulocytic Sarcoma is also known as myeloid sarcoma, chloroma, extramedullary myeloblastoma, and extramedullary myeloid tumor. The patient went on to have a resection which histologically confirmed chloroma (also known as a granulocytic sarcoma or myeloid sarcoma) of the occipital bone. This patient developed pleural and pulmonary involvement by primary granulocytic sarcoma. This is a preview of subscription … Destruction of cervical vertebrae Case of the Week #110. Unravelling chloroma: review of imaging findings. Usually history of myeloid neoplasm, most often acute myeloid leukemia, less often a myelodysplastic or myeloproliferative disease Testicular involvement can be initial manifestation of … Marcos D. Guimarães 1, Edson Marchiori 2, Edith M. Marom 3, Mark J. Routbort 4 & Myrna C. B. Godoy 3 Annals of Hematology volume 93, pages 327 – 328 (2014)Cite this article. Guimarães MD, Marchiori E, Marom EM, Routbort MJ, Godoy MCB. 1994;190:698–702. The imaging revealed the presence of a cardiac infiltrative mass involving the heart’s right free wall that proved to be a chloroma. Chloroma is a rare, malignant tumor made up of granulocyte precursor cells. The tumor rarely occurs in the absence of concurrent or remote peripheral blood or bone marrow involvement by leukemia. 1. ... K, , Kulpraneet M, , Panichchob P, , Tantisiriwat W. Acute monoblastic leukemia with t(10;11)(p12;q23) presenting with pulmonary involvement: a case report and literature review. The patient went on to have a resection which histologically confirmed chloroma (also known as a granulocytic sarcoma or myeloid sarcoma) of the occipital bone. Evaluation included pleural biopsy, bronchoscopy, bone marrow biopsy, endomyocardial biopsy and ultimately thoracotomy. Chemoradiation was administered with initial response, however, disease progression led to the patients´death. Systemic chemotherapy should be started early, even in the non-leukemic disease stage. RANULOCYTIC SARCOMA (or chloroma) has at- tracted considerable attention because of its close association with the various myeloproliferative dis- orders,' most often acute or chronic leukemia. A CT was requested to rule out pulmonary embolism. Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia. Guimaraes in 2013 reported a case of pulmonary granulocytic sarcoma mimicking an opportunistic infection in a patient with acute myeloid leukaemia. It is a rare solid tumor composed of primitive precursors of the granulocytic series of white blood cells that include myeloblasts, promyelocytes, and myelocytes The tumor is an extramedullary manifestation of acute myeloid leukemia (AML). Previously, only small studies investigated clinical and imaging features of MS. Prognostic factors. Granulocytic sarcoma (chloroma) american journal of. Granulocytic sarcoma, also known as chloroma or extramedullary myeloblastoma, is a rare solid tumor composed of primitive precursors of the granulocytic series of wbc. Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia. doi: 10.1097/MPH.0000000000001085. Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia . Upon occasion, granulocytic sarcoma can actually appear as the initial manifestation of a myeloproliferative state. Pulmonary granulocytic sarcoma (chloroma) mimicking an opportunistic infection in a patient with acute myeloid leukemia. Therefore, the history of myelogenous leukaemia is an important hint towards the correct diagnosis in this case. Cardiac Chloroma Clinically Resembling Pulmonary Embolism in the Emergency Setting. Radiological findings include lung mass or cavitation with or without associated lymphadenopathy. Acute myeloid leukemia (AML) can involve the orbit as a solid tumor termed myeloid sarcoma or chloroma. Pui MH, Fletcher BD, Langston JW. (Chest 1988; 94:655-56) Untreated isolated chloroma ultimately transforms to Common sites of involvement include … Reprints: Jessica L. Heath, MD, Department of Pediatrics, 89 Beaumont Avenue, Given Courtyard, S259, Burlington, VT 05405 (e-mail: [email protected]). The imaging revealed the presence of a cardiac infiltrative mass involving the heart’s right free wall that proved to be a chloroma. Radiology. 1996;11:223-30. Metrics details. § Division of Pediatric Radiology, Duke University, Durham, NC. A 36-year-old woman presented with cough, pleural effusion and atelectasis. In this case, if the blurring effect of respiration is properly evaluated, the roentgen diagnosis of a tuberculous process was illogical. 7. 2013:10–11 (E-pub ahead of print). It was formerly known as granulocytic sarcoma, chloroma, or myeloblastoma. A CT was requested to rule out pulmonary embolism. Publicationdate december 20, 2007. J Thorac Imaging. High signal intensity. Ann Hematol. Journal of Pediatric Hematology/Oncology: October 2018 - Volume 40 - Issue 7 - p e442-e445. Guimarães MD, Marchiori E, Marom EM, Routbort MJ, Godoy MCB. Surgery and/or radiotherapy may be indicated for symptomatic lesions or tumors causing local organ dysfunction or obstruction [31]. A systemic review of imaging findings in chloroma is presented here (Table 1) along with site-specific common differential considerations. imaging findings is broad and includes lymphoma and sarcomas [32]. A literature review suggests that leukemia might be the most likely diagnosis in a child with bilateral soft tissue orbital tumors, a point that has not been widely recognized. 6. 3 Citations. It is also called granulocytic sarcoma or extramedullary myeloblastoma and is … The diagnosis of granulocytic sarcoma involving lungs and pleura but not bone marrow was made histologically. [Google Scholar] 29 . Magnetic resonance imaging was done confirming the echocardiographic results and showing even involvement of pulmonary veins, coronary arteries and myocardial infiltration. Lateral view showing soft-tissue mass of fairly uniform thickness behind the sternum. An unusual case of pulmonary granulocytic sarcoma treated with combined chemotherapy and radiation ... also called chloroma, extramedullary leukaemia, myeloid sarcoma (MS), or myeloblastoma, is an unusual extramed- ullary tumour of immature myeloid cells [1]. Bone (subperiosteal) and perineural involvement is common, whereas thoracic involvement is uncommon. The radiology assistant lung hrct common diseases. Granulocytic sarcoma, an uncommon solid, extra-medullary tumor is a rare presentation of acute myeloid leukemia. 0 Altmetric. History: … Figure 1. Albert Pons Escoda, Diego Nova Vaca, Lucía Aja Rodríguez, Matías De Albert de Delás Vigo, Fernando Fernández Alarza Abstract Full-Text PDF Full-Text HTML Full-Text ePUB Linked References How to Cite this Article. A seven-year old boy admitted to the hospital for treatment of leukemia having radiological findings of consolidation in one lung. 7. Leukemic pulmonary infiltration is defined as … Hermann G, , Feldman F, , Abdelwahab IF, , Klein MJ. ... also called chloroma, extramedullary leukaemia, myeloid sarcoma (MS), or myeloblastoma, is an unusual extramedullary tumour of immature myeloid cells . In some patients, calcification and sequestered bone fragments are seen as well. We report the case of a 52-year-old man with a history of acute myeloid leukemia who presented to the emergency room with fatigue, dyspnea and chest pain. Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. 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